A South Indian Digest of Commentaries on the Nyāyasūtra

The Nyāyasūtravivaraṇa, written in the first centuries of the 2nd millennium CE, provides the most accessible introduction to the core teachings of old Nyāya. Excerpting from the two earliest and most important treatises of this tradition—the Nyāyabhāṣya and Nyāyavārttika—Gambhīravaṃśaja created a comprehensive yet concise digest. The present work contains not only a critical edition of the first chapter based on all known textual sources but also a complete documentation of the variants, a comprehensive study of the parallel passages, a detailed discussion of the preparation and processing of the text-critical data, and a detailed documentation of the Grantha Tamil, Telugu and Kannada scripts.Das Nyāyasūtravivaraṇa, geschrieben in den ersten Jahrhunderten des 2. Jahrtausends u. Z., bietet die zugänglichste Einführung in die Kernlehren des alten Nyāya. Anhand von Auszügen aus den beiden frühesten und wichtigsten Abhandlungen dieser Tradition – dem Nyāyabhāṣya und dem Nyāyavārttika – schuf Gambhīravaṃśaja ein umfassendes und doch prägnantes Digest. Das vorliegende Werk enthält nicht nur eine kritische Ausgabe des ersten Kapitels basierend auf allen bekannten Textquellen, sondern auch eine vollständige Dokumentation der Varianten, eine umfassende Studie der Parallelstellen, eine detaillierte Erörterung der Aufbereitung und Verarbeitung von textkritischen Daten sowie eine ausführliche Dokumentation der Grantha Tamil-, Telugu- und Kannada-Schriften

Arthritis: where are the T cells?

T-helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce antibodies, by producing cytokines that activate effector cells involved in the destruction of cartilage and bone, and by contributing to osteoclast differentiation. There are murine models of arthritis, most notably collagen- and proteoglycan-induced arthritis, in which arthritis depends on T-cell recognition of antigens that are expressed in the joints. In spite of this, we still do not know the antigens recognised by arthritogenic Th cells in humans. Moreover, current evidence for Th cells exerting arthritogenic effector functions within the joints is only indirect

A South Indian Digest of Commentaries on the Nyāyasūtra

The Nyāyasūtravivaraṇa, written in the first centuries of the 2nd millennium CE, provides the most accessible introduction to the core teachings of old Nyāya. Excerpting from the two earliest and most important treatises of this tradition—the Nyāyabhāṣya and Nyāyavārttika—Gambhīravaṃśaja created a comprehensive yet concise digest. The present work contains not only a critical edition of the first chapter based on all known textual sources but also a complete documentation of the variants, a comprehensive study of the parallel passages, a detailed discussion of the preparation and processing of the text-critical data, and a detailed documentation of the Grantha Tamil, Telugu and Kannada scripts

Critical incidents in paediatric critical care: who is at risk?

We evaluated the characteristics of children for whom critical incidents (CIs) were reported by performing prospective collection of patient data and retrospective review of reported CIs in a multidisciplinary neonatal-paediatric intensive care unit of a tertiary care university children's hospital. A period of 1year was analysed (January to December 2007; 1,251 admissions). CIs comprised adverse events (actual patient injury), as well as near-misses. The report form of critical incidents was web-based and reporting was voluntary, anonymous and non-punitive. The severity of all CIs was divided into minor, moderate and major. Patients with and without CIs were compared regarding the following characteristics: Paediatric Index of Mortality (PIM2), duration of mechanical ventilation, length of stay in the intensive care, admission mode (surgery, cardiopulmonary bypass, cardiac/non-cardiac unit), age and sex. There were 360 CI reports (83 per 1,000 patient days; 13% major, 26% moderate, 61% minor severity). Of these, 310 CIs could be assigned to 198 specific patients. In the univariate analysis, patient-related risk factors for CIs were higher PIM2 score (p < 0.0001), increased length of stay (p < 0.0001), mechanical ventilation (p < 0.0001), increased ventilator days (p < 0.0001), male gender (p = 0.022) and young age (p < 0.0001). Using a logistic regression model, mechanical ventilation (p < 0.0001), male gender (p = 0.034) and length of stay (p < 0.0001) continued to be associated with the occurrence of CIs. Conclusion CIs often occur in paediatric intensive care. Among the patient-related factors, male gender, mechanical ventilation, and length of stay are independently associated with CIs. Already known at admission to intensive care are male gender and, usually, requirement for mechanical ventilation. Improved knowledge of the risk factors for CIs could help to minimize their frequency and thus improve quality of car

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